|
KMID : 0665220070200020125
|
|
Korean Journal of Food and Nutrition
2007 Volume.20 No. 2 p.125 ~ p.133
|
|
|
Effect of Zingiber officinale Roscoe Fractionation of Extracts on Mouse Spleen and Macrophage Cells Activation
|
|
Ryu Hye-Sook
|
|
|
Abstract
|
|
|
|
Ginger(Zingiber officinale Roscoe) has long been used as a food source in Korea, and it is widely used as a dietary condiment throughout the world. The present study focused on the immunomodulative effects of ginger extracts via in vitro experiments. To identify the immune-activation fractions of the plant, we performed the systematic fractionation of ginger with methanol, hexane, chloroform, butanol and water for separation and refining. The results showed that the chloroform fraction had the highest immune cell activation properties. In conclusion, this study suggests that ginger extracts may enhance immune function by regulating the splenocyte proliferation as well as the cytokine production capacity of activated macrophages.
|
|
|
KEYWORD
|
|
|
chloroform fraction, immunomodulative, splenocyte proliferation, IL-1 β, IL-6, TNF-α
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|